Health
3:04 am
Mon April 15, 2013

How Exercise And Other Activities Beat Back Dementia

Originally published on Tue April 16, 2013 8:45 am

The numbers are pretty grim: More than half of all 85-year-olds suffer some form of dementia.

But here's the good news: Brain researchers say there are ways to boost brain power and stave off problems in memory and thinking.

In other words, brain decline is not necessarily an inevitable part of aging. "It's simply not pre-destined for all human beings," Bryan James tells Shots. He's an epidemiologist at the Rush Alzheimer's Disease Center in Chicago. "Lots of people live into their 90s and even 100s with no symptoms of dementia."

So what can you do to increase the odds? Neuroscientist Art Kramer, who directs the Beckman Institute for Advanced Science and Technology at the University of Illinois, has a number of suggestions. First and foremost, Kramer says, is to exercise. Research shows it's the best thing you can do for your brain.

Kramer did a study in which he scanned the brains of 120 older adults, half of whom started a program of moderate aerobic exercise — just 45 minutes, three days a week, mostly walking. After a year, the MRI scans showed that for the aerobic group, the volume of their brains actually increased.

What's more, individuals in the control group lost about 1.5 percent of their brain volume, adding up to a 3.5 percent difference between individuals who took part in aerobic exercise and those who did not. Further tests showed that increased brain volume translated into better memory.

The findings support earlier animal research in which rodents that were exercised had a number of favorable physiological changes, Kramer says. They had more new neurons, stronger connections between neurons, and increased blood supply to a number of regions in the brain.

Rachel Whitmer, a researcher at Kaiser Permanente in Northern California, agrees that it's important to exercise your body to ensure the health of your brain. It's not just getting adequate exercise, Whitmer says, it's also "maintaining good blood pressure, levels of cholesterol and a healthy weight," and remembering that "what's good for the heart is good for the brain."

What about mental exercises? Kramer says the evidence isn't nearly as conclusive, but keeping your brain active can't hurt.

The brain loves novelty, so if you do crossword puzzles, try shifting to a different type of puzzle — Sudoku, for example, he says. Or learn a new language. Play a new instrument.

And go out with friends. James recently published a study looking at the social lives of about 1,100 adults over 80. He asked them about going to restaurants and sporting events, playing bingo, doing volunteer work and other activities.

Individuals were followed for up to 12 years. Those with busy social lives were half as likely to develop dementia, compared with those with minimal social activities.

In another study, James looked at a different measure of activity — something he calls "life space." He added up how often people got out of their bedroom, went out of their house, traveled out of their neighborhood or out of town. "The people who never left their home — even though they didn't seem to have any cognitive problems when we started following them — were twice as likely to develop Alzheimer's disease" over five years, James says.

And finally, there's the popular notion of brain food. There's some evidence suggesting that omega-3 fatty acids, found in fish, and antioxidants, like vitamins C and E, found in vegetables, may help nourish the brain.

Putting it all together, Kramer jokingly suggests that the best advice might be to join a book group that walks and drinks red wine while talking about the book. Red wine contains antioxidants, Kramer notes. You'd be discussing a stimulating topic with good friends while exercising your body. "How can you beat it?" he says. "It's got all four!"

Copyright 2013 NPR. To see more, visit http://www.npr.org/.

Transcript

STEVE INSKEEP, HOST:

OK, not everybody can be a super-ager. But many brain researchers agree that declines in memory are not necessarily inevitable. As NPR's Patti Neighmond reports, there are things we can do to keep dementia at bay.

PATTI NEIGHMOND, BYLINE: You may be surprised to hear that the best thing you can probably do for your brain is exercise your body. Neuroscientist Art Kramer, with the University of Illinois, has studied the impact of aerobic exercise.

ART KRAMER: Walking, jogging, swimming, aerobic exercise in the pool, or riding your bike.

NEIGHMOND: In Kramer's study, participants had brain scans before and after they started a program of moderate aerobic exercise - just 45 minutes, three days a week; mostly walking. After a year, Kramer found the volume of their brains actually increased. And that translated into a better memory. Kramer points to earlier research that found significant changes in the brains of rodents when they exercised.

KRAMER: It increases the number of new neurons, the computational factories in the brain; it increases the effectiveness of connections between different brain regions; and also increases the blood supply to various regions of the brain.

NEIGHMOND: So one more reason to get up and get moving. And while the evidence isn't nearly as conclusive when it comes to mental exercise, keeping your brain active can't hurt, says Kramer. Take his 93-year-old aunt, Angela Little, a retired science professor at the University of California, Berkeley. She's currently taking a course in Italian literature.

ANGELA LITTLE: We read Dante, we read "The Inferno," we read Boccaccio.

NEIGHMOND: It's a two-hour class involving discussion and historical analysis. I ask if it's taught in English.

LITTLE: Oh, no, no, no, no. Everything is in Italian. We don't speak English at all; everything is in Italian, absolutely - assolutamente.

(LAUGHTER)

NEIGHMOND: It's learning new things that seems to offer the biggest benefit. So new novels are good. If you do crossword puzzles, try shifting to Suduko - a puzzle that uses numbers. Learn a new language. Play a new instrument. The brain likes novelty, says Kramer, whose aunt enjoys another important activity - socializing.

LITTLE: I've outlived my generation - this is true - but I've inherited the children of my departed friends, and they're now my friends. And we go to lunch together, go to museums together, or just sit around and chit-chat or play Scrabble, or something like that.

NEIGHMOND: Studies have shown that just the act of getting together with friends may help stimulate the brain. Bryan James is an epidemiologist at the Rush Alzheimer's Disease Center in Chicago. He recently looked at the social lives of about 1,100 adults over 80.

BRYAN JAMES: So we asked people about going to restaurants, going to sporting events, playing bingo and other social games like that; doing unpaid community and volunteer work, going on day trips.

NEIGHMOND: Individuals were followed for up to 12 years. Those with busy social lives were half as likely to develop dementia, compared to those who weren't socially active. In another study, Adams looked at something he calls life space. [POST-BROADCAST CORRECTION: The epidemiologist's last name was misstated. It is James.] He added up how often people literally got out of their bedroom, went out of their house, traveled out of their neighborhood or out of town.

JAMES: The people who never left their home - even though they didn't seem to have any cognitive problems, when we started following them - were twice as likely to develop Alzheimer's disease over that five-year time period.

NEIGHMOND: And finally, the notion of brain food. Some evidence suggests that omega-3 fatty acids, found in fish; and antioxidants, found in vegetables and red wine; may help nourish the brain - leading neuroscientist Art Kramer to suggest this...

KRAMER: The walking book group with good red wine: You walk; you talk about something stimulating - a book that you've read - with good friends. How can you beat it? It's got all four.

NEIGHMOND: Good food, social activity, intellectual challenge and most important of all, physical exercise.

Patti Neighmond, NPR News.

(SOUNDBITE OF MUSIC) Transcript provided by NPR, Copyright NPR.

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